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KMID : 1009020210190040721
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Clinical Psychopharmacology and Neuroscience
2021 Volume.19 No. 4 p.721 ~ p.730
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Relationship between Handgrip Strength and Low-grade Inflammation in Older Adults with Depression
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Kang Kwi-Young
Jung Young-Eun
Jang Hwan
Kim Moon-Doo
Bahk Won-Myong
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Abstract
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Objective: The relationship among physical functional decline, low-grade inflammation, and depression remains unclear. The aim of this study was to examine the association between hand grip strength (HGS) and high-sensitivity C-reactive protein (hs-CRP) in a large sample with depression.
Methods: This study used data obtained from a representative Korean sample of 9,402 people who participated in the seventh Korean National Health and Nutrition Examination Survey. Physical function was assessed using a digital grip strength dynamometer. Depression was identified using a cutoff of 5 on the Patient Health Questionnaire-9 (PHQ-9), and high hs-CPR level was defined as ≥ 3.0 mg/L.
Results: In older adults (≥ 60 years) with depression, 43.8% of those with high hs-CRP levels had low HGS, compared to 21.8% of those with hs-CRP levels < 3.0 mg/L (p = 0.002). Multivariate analysis revealed that, after adjustments for potentially confounding factors, high hs-CRP was independently associated with lower HGS (B = ?2.25; 95% confidence interval = ?4.49 to ?0.02) in older adults with depression, but not in younger or middle-aged adults with depression.
Conclusion: These findings suggest a significant correlation between physical functional decline and low-grade inflammation in older adults with depression.
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KEYWORD
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Hand grip strength, C-reactive protein, PHQ-9, Depression, Inflammation, Older adults
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